Autism, Schizophrenia and Bipolar Disorder May Share Common Underlying Factors
July 12, 2012
By Autism Society
New research led by Patrick F. Sullivan, MD, FRANZCP, a psychiatric geneticist at the University of North Carolina School of Medicine, points to an increased risk of autism spectrum disorders among individuals whose parents or siblings have been diagnosed with schizophrenia or bipolar disorder.
The findings were based on a case-control study using population registers in Sweden and Israel, and the degree to which these three disorders share a basis in causation “has important implications for clinicians, researchers and those affected by the disorders,” according to a report of the research published online July 2 in the Archives of General Psychiatry.
“The results were very consistent in large samples from several different countries and lead us to believe that autism and schizophrenia are more similar than we had thought,” said Dr. Sullivan, professor in the department of genetics and director of psychiatric genomics at UNC.
Sullivan and colleagues found that the presence of schizophrenia in parents was associated with an almost three times increased risk for ASD in groups from both Stockholm and all of Sweden.
Schizophrenia in a sibling also was associated with roughly two and a half times the risk for autism in the Swedish national group and a 12 times greater risk in a sample of Israeli military conscripts. The authors speculate that the latter finding from Israel resulted from individuals with earlier onset schizophrenia, “which has a higher sibling recurrence.”
Bipolar disorder showed a similar pattern of association but of a lesser magnitude, study results indicate.
"Our findings suggest that ASD, schizophrenia and bipolar disorder share etiologic risk factors,” the authors state. “We suggest that future research could usefully attempt to discern risk factors common to these disorders.”
Adapted from a UNC Health Care News Release.
April 10, 2013
The Autism Society, the nation’s largest and oldest grassroots autism organization, has chosen Pittsburgh as the host city of its 44th annual conference on autism spectrum disorders.
April 5, 2013
Individuals with autism can attend the Autism Society National Conference and Exposition (in Pittsburgh) for FREE this year! Learn more: www.autism-society.org/conference.
April 3, 2013
Monarch Teaching Technologies, the makers of VizZle®, web-based educational software for visual learners with autism, will give one-year of free VizZle to every new (or renewing) Champion Member during April.
April 2, 2013
Read the Autism Society’s digital magazine about autism spectrum disorders!
April 2, 2013
Today, throughout the world, individuals will come together highlighting the needs and dreams of people living with autism.